重组人ErbB2 / HER2蛋白 产品货号#: 10004-H08H 规格(价格) X 收藏该产品 Receptor Tyrosine-Protein Kinase erbB-2 ( ErbB2 / CD340 ) Protein ErbB2 / CD340 Protein Price Inquiry ( Available Sizes ) 500μg: 询价; ≥1mg 大包装: 询价 ErbB2 / CD340蛋白产品信息 别名: ErbB2, NEU, NGL, HER2, TKR1, CD340, HER-2, c-erb B2, HER-2/neu 表达方式: A DNA sequence encoding the extracellular domain ( Met 1- Thr 652 ) of human ErbB2 ( NP_004439.2 ) was fused with the polyhistidine tag at the C-terminus 种属: Human 表达宿主: Human Cells ErbB2 / CD340蛋白质控指标 纯度: ﹥ 97 % as determined by SDS-PAGE. SDS-PAGE: ErbB2 protein 内毒素: < 1.0 EU per μg of the protein as determined by the LAL method. 稳定性: Samples are stable for up to twelve months from date of receipt at -70°C 预测N端: Thr 23 分子量: The recombinant human ErbB2 comprises 641 amino acids and has a calculated molecular mass of 71 KDa. As a result of glycosylation, rh ErbB2 migrates as an approximately 100-110 KDa protein in SDS-PAGE under reducing conditions. 缓冲液: Lyophilized from sterile PBS , pH 7.4 ErbB2 / CD340蛋白使用指南 储存方法: Store it under sterile conditions at -70°C immediately after receipt. It is recommended to aliquot the protein for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. ErbB2 / CD340蛋白相关产品和研究主题 ErbB2 / HER2 Protein 相关研究领域: Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>HER2/ErbB2 Cancer>>Cancer Biomarkers>>HER2/ErbB2 Cancer>>Growth Factor & Receptor>>EGF Family & Receptor>>HER2/ErbB2 Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>HER2/ErbB2 Immunology>>Cluster of Differentiation>>Other>>HER2/ErbB2/CD340 蛋白: Molecule Species Description //For Detailed Info. and Price Cat No HER2/ErbB2 Human HER2/ErbB2 Protein, Recombinant 10004-H08H HER2/ErbB2 Human HER2/ErbB2/Fc Protein, Recombinant 10004-H02H 抗体: Molecule Application Description //For Detailed Info. and Price Cat No Human HER2/ErbB2 ELISA Mouse Monoclonal Antibody 10004-MM01 Human HER2/ErbB2 WB Mouse Monoclonal Antibody 10004-MM02 Human HER2/ErbB2 ELISA Mouse Monoclonal Antibody (Biotin conjugated) 10004-MM01B Human HER2/ErbB2 WB Mouse Monoclonal Antibody (Biotin conjugated) 10004-MM02B Human HER2/ErbB2 WB, ELISA Rabbit Monoclonal Antibody 10004-R002 Human HER2/ErbB2 ELISA Rabbit Polyclonal Antibody 10004-RP03 Human HER2/ErbB2 WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 10004-RP04 ErbB2 / CD340蛋白背景综述 ErbB2, also known as NEU and HER2, is a typeⅠmembrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases(RTKs). ErbB2 cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, this receptor forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. Since ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays an key role in development, cell proliferation and differentiation. ErbB2 is widely expressed in epithelial cells, and amplification and/or overexpression of the this gene has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. 参考文献 Yamamoto, T. et al., 1986, Nature. 319: 230-234. Nathan J. 2001, J. Biol. Chem. 276:42153-42161. Codony-Seeervat, J. et al., 1999, Cancer Res. 59: 1196-1201. Tzahar, E. et al., 1998, Biochim. Biophys. Acta. 1377: 25-37 Kermit, L. et al, 1999, J. Biol. Chem. 274: 5263-5266. Ying-Xin Fan. et al., 2008, J. Biol. Chem. 283: 1588-1596.
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