重组人ErbB2 / HER2蛋白

产品货号#:

10004-H08H

规格(价格)

X

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Receptor Tyrosine-Protein Kinase erbB-2 ( ErbB2 / CD340 ) Protein

ErbB2 / CD340 Protein Price Inquiry ( Available Sizes )

500μg: 询价;

≥1mg 大包装: 询价

ErbB2 / CD340蛋白产品信息

别名:

ErbB2, NEU, NGL, HER2, TKR1, CD340, HER-2, c-erb B2, HER-2/neu

表达方式:

A DNA sequence encoding the extracellular domain ( Met

1- Thr 652 ) of human ErbB2 ( NP_004439.2 ) was fused with the

polyhistidine tag at the C-terminus

种属:

Human

表达宿主:

Human Cells

ErbB2 / CD340蛋白质控指标

纯度:

﹥ 97 % as determined by SDS-PAGE.

SDS-PAGE:

ErbB2 protein

内毒素:

< 1.0 EU per μg of the protein as determined by the LAL method.

稳定性:

Samples are stable for up to twelve months from date of receipt at -70°C

预测N端:

Thr 23

分子量:

The recombinant human ErbB2 comprises 641 amino acids

and has a calculated molecular mass of 71 KDa. As a result of

glycosylation, rh ErbB2 migrates as an approximately 100-110 KDa

protein in SDS-PAGE under reducing conditions.

缓冲液:

Lyophilized from sterile PBS , pH 7.4

ErbB2 / CD340蛋白使用指南

储存方法:

Store it under sterile conditions at -70°C immediately

after receipt. It is recommended to aliquot the protein for optimal

storage. Avoid repeated freeze-thaw cycles.

Reconstitution:

A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ErbB2 / CD340蛋白相关产品和研究主题

ErbB2 / HER2 Protein 相关研究领域:

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>HER2/ErbB2

Cancer>>Cancer Biomarkers>>HER2/ErbB2

Cancer>>Growth Factor & Receptor>>EGF Family & Receptor>>HER2/ErbB2

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>HER2/ErbB2

Immunology>>Cluster of Differentiation>>Other>>HER2/ErbB2/CD340

蛋白:

Molecule

Species

Description //For Detailed Info. and Price

Cat No

HER2/ErbB2

Human

HER2/ErbB2 Protein, Recombinant

10004-H08H

HER2/ErbB2

Human

HER2/ErbB2/Fc Protein, Recombinant

10004-H02H

抗体:

Molecule

Application

Description //For Detailed Info. and Price

Cat No

Human

HER2/ErbB2

ELISA

Mouse Monoclonal Antibody

10004-MM01

Human

HER2/ErbB2

WB

Mouse Monoclonal Antibody

10004-MM02

Human

HER2/ErbB2

ELISA

Mouse Monoclonal Antibody (Biotin conjugated)

10004-MM01B

Human

HER2/ErbB2

WB

Mouse Monoclonal Antibody (Biotin conjugated)

10004-MM02B

Human

HER2/ErbB2

WB, ELISA

Rabbit Monoclonal Antibody

10004-R002

Human

HER2/ErbB2

ELISA

Rabbit Polyclonal Antibody

10004-RP03

Human

HER2/ErbB2

WB, ELISA

Rabbit Polyclonal Antibody (Antigen Affinity Purified)

10004-RP04

ErbB2 / CD340蛋白背景综述

ErbB2, also known as NEU and HER2, is a typeⅠmembrane glycoprotein,

and belongs to the epidermal growth factor (EGF) receptor family of

receptor tyrosine kinases(RTKs). ErbB2 cannot bind growth factors due

to the lacking of ligand binding domain of its own and autoinhibited

constitutively. However, this receptor forms a heterodimer with other

ligand-bound EGF receptor family members, therefore stabilizes ligand

binding and enhances kinase-mediated activation of downstream molecules.

Since ErbB2 mediates signalling pathways which involve

mitogen-activated protein kinase and phosphatidylinositol-3 kinase,

this receptor plays an key role in development, cell proliferation and

differentiation. ErbB2 is widely expressed in epithelial cells, and

amplification and/or overexpression of the this gene has been reported

associated with malignancy and a poor prognosis in numerous carcinomas,

including breast, prostate and ovarian cancers.

参考文献

Yamamoto, T. et al., 1986, Nature. 319: 230-234.

Nathan J. 2001, J. Biol. Chem. 276:42153-42161.

Codony-Seeervat, J. et al., 1999, Cancer Res. 59: 1196-1201.

Tzahar, E. et al., 1998, Biochim. Biophys. Acta. 1377: 25-37

Kermit, L. et al, 1999, J. Biol. Chem. 274: 5263-5266.

Ying-Xin Fan. et al., 2008, J. Biol. Chem. 283: 1588-1596.